diff --git a/ChangeLog.d/spm_build.txt b/ChangeLog.d/spm_build.txt
new file mode 100644
index 000000000..6016d84e0
--- /dev/null
+++ b/ChangeLog.d/spm_build.txt
@@ -0,0 +1,4 @@
+Bugfix
+   * When MBEDTLS_PSA_CRYPTO_SPM is enabled, crypto_spe.h was not included
+     in all the right places. Include it from crypto_platform.h, which is
+     the natural place. Fixes #4649.
diff --git a/include/psa/crypto_platform.h b/include/psa/crypto_platform.h
index 8acf22c7f..66f468793 100644
--- a/include/psa/crypto_platform.h
+++ b/include/psa/crypto_platform.h
@@ -81,6 +81,18 @@ static inline int mbedtls_key_owner_id_equal( mbedtls_key_owner_id_t id1,
 
 #endif /* MBEDTLS_PSA_CRYPTO_KEY_ID_ENCODES_OWNER */
 
+/*
+ * When MBEDTLS_PSA_CRYPTO_SPM is defined, the code is being built for SPM
+ * (Secure Partition Manager) integration which separates the code into two
+ * parts: NSPE (Non-Secure Processing Environment) and SPE (Secure Processing
+ * Environment). When building for the SPE, an additional header file should be
+ * included.
+ */
+#if defined(MBEDTLS_PSA_CRYPTO_SPM)
+#define PSA_CRYPTO_SECURE 1
+#include "crypto_spe.h"
+#endif // MBEDTLS_PSA_CRYPTO_SPM
+
 #if defined(MBEDTLS_PSA_CRYPTO_EXTERNAL_RNG)
 /** The type of the context passed to mbedtls_psa_external_get_random().
  *
diff --git a/library/psa_crypto.c b/library/psa_crypto.c
index 775923af5..845fc74bb 100644
--- a/library/psa_crypto.c
+++ b/library/psa_crypto.c
@@ -26,7 +26,6 @@
 #include "check_crypto_config.h"
 #endif
 
-#include "psa_crypto_service_integration.h"
 #include "psa/crypto.h"
 
 #include "psa_crypto_cipher.h"
diff --git a/library/psa_crypto_client.c b/library/psa_crypto_client.c
index e84cf3015..629feb7df 100644
--- a/library/psa_crypto_client.c
+++ b/library/psa_crypto_client.c
@@ -19,7 +19,6 @@
  */
 
 #include "common.h"
-#include "psa_crypto_service_integration.h"
 #include "psa/crypto.h"
 
 #if defined(MBEDTLS_PSA_CRYPTO_CLIENT)
diff --git a/library/psa_crypto_service_integration.h b/library/psa_crypto_service_integration.h
deleted file mode 100644
index 87889af49..000000000
--- a/library/psa_crypto_service_integration.h
+++ /dev/null
@@ -1,39 +0,0 @@
-/*
- *  Copyright The Mbed TLS Contributors
- *  SPDX-License-Identifier: Apache-2.0
- *
- *  Licensed under the Apache License, Version 2.0 (the "License"); you may
- *  not use this file except in compliance with the License.
- *  You may obtain a copy of the License at
- *
- *  http://www.apache.org/licenses/LICENSE-2.0
- *
- *  Unless required by applicable law or agreed to in writing, software
- *  distributed under the License is distributed on an "AS IS" BASIS, WITHOUT
- *  WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
- *  See the License for the specific language governing permissions and
- *  limitations under the License.
- */
-
-#ifndef PSA_CRYPTO_SERVICE_INTEGRATION_H
-#define PSA_CRYPTO_SERVICE_INTEGRATION_H
-
-/*
- * When MBEDTLS_PSA_CRYPTO_SPM is defined, the code is being built for SPM
- * (Secure Partition Manager) integration which separates the code into two
- * parts: NSPE (Non-Secure Processing Environment) and SPE (Secure Processing
- * Environment). When building for the SPE, an additional header file should be
- * included.
- */
-#if defined(MBEDTLS_PSA_CRYPTO_SPM)
-/*
- * PSA_CRYPTO_SECURE means that the file which included this file is being
- * compiled for SPE. The files crypto_structs.h and crypto_types.h have
- * different implementations for NSPE and SPE and are compiled according to this
- * flag.
- */
-#define PSA_CRYPTO_SECURE 1
-#include "crypto_spe.h"
-#endif // MBEDTLS_PSA_CRYPTO_SPM
-
-#endif // PSA_CRYPTO_SERVICE_INTEGRATION_H
diff --git a/library/psa_crypto_slot_management.c b/library/psa_crypto_slot_management.c
index 0b1a3c166..672388531 100644
--- a/library/psa_crypto_slot_management.c
+++ b/library/psa_crypto_slot_management.c
@@ -22,7 +22,6 @@
 
 #if defined(MBEDTLS_PSA_CRYPTO_C)
 
-#include "psa_crypto_service_integration.h"
 #include "psa/crypto.h"
 
 #include "psa_crypto_core.h"
diff --git a/library/psa_crypto_storage.c b/library/psa_crypto_storage.c
index 773d3aaaf..2ebfc26a8 100644
--- a/library/psa_crypto_storage.c
+++ b/library/psa_crypto_storage.c
@@ -29,7 +29,6 @@
 #include <stdlib.h>
 #include <string.h>
 
-#include "psa_crypto_service_integration.h"
 #include "psa/crypto.h"
 #include "psa_crypto_storage.h"
 #include "mbedtls/platform_util.h"