diff --git a/programs/ssl/ssl_test_lib.c b/programs/ssl/ssl_test_lib.c
index 84553df71..46cea144c 100644
--- a/programs/ssl/ssl_test_lib.c
+++ b/programs/ssl/ssl_test_lib.c
@@ -63,7 +63,14 @@ static int dummy_entropy( void *data, unsigned char *output, size_t len )
 
 void rng_init( rng_context_t *rng )
 {
+#if defined(MBEDTLS_CTR_DRBG_C)
     mbedtls_ctr_drbg_init( &rng->drbg );
+#elif defined(MBEDTLS_HMAC_DRBG_C)
+    mbedtls_hmac_drbg_init( &rng->drbg );
+#else
+#error "No DRBG available"
+#endif
+
     mbedtls_entropy_init( &rng->entropy );
 }
 
@@ -75,10 +82,28 @@ int rng_seed( rng_context_t *rng, int reproducible, const char *pers )
     if ( reproducible )
         srand( 1 );
 
+#if defined(MBEDTLS_CTR_DRBG_C)
     int ret = mbedtls_ctr_drbg_seed( &rng->drbg,
                                      f_entropy, &rng->entropy,
                                      (const unsigned char *) pers,
                                      strlen( pers ) );
+#elif defined(MBEDTLS_HMAC_DRBG_C)
+#if defined(MBEDTLS_SHA256_C)
+    const mbedtls_md_type_t md_type = MBEDTLS_MD_SHA256;
+#elif defined(MBEDTLS_SHA512_C)
+    const mbedtls_md_type_t md_type = MBEDTLS_MD_SHA512;
+#else
+#error "No message digest available for HMAC_DRBG"
+#endif
+    int ret = mbedtls_hmac_drbg_seed( &rng->drbg,
+                                      mbedtls_md_info_from_type( md_type ),
+                                      f_entropy, &rng->entropy,
+                                      (const unsigned char *) pers,
+                                      strlen( pers ) );
+#else
+#error "No DRBG available"
+#endif
+
     if( ret != 0 )
     {
         mbedtls_printf( " failed\n  ! mbedtls_ctr_drbg_seed returned -0x%x\n",
@@ -91,14 +116,27 @@ int rng_seed( rng_context_t *rng, int reproducible, const char *pers )
 
 void rng_free( rng_context_t *rng )
 {
+#if defined(MBEDTLS_CTR_DRBG_C)
     mbedtls_ctr_drbg_free( &rng->drbg );
+#elif defined(MBEDTLS_HMAC_DRBG_C)
+    mbedtls_hmac_drbg_free( &rng->drbg );
+#else
+#error "No DRBG available"
+#endif
+
     mbedtls_entropy_free( &rng->entropy );
 }
 
 int rng_get( void *p_rng, unsigned char *output, size_t output_len )
 {
     rng_context_t *rng = p_rng;
+#if defined(MBEDTLS_CTR_DRBG_C)
     return( mbedtls_ctr_drbg_random( &rng->drbg, output, output_len ) );
+#elif defined(MBEDTLS_HMAC_DRBG_C)
+    return( mbedtls_hmac_drbg_random( &rng->drbg, output, output_len ) );
+#else
+#error "No DRBG available"
+#endif
 }
 
 #if defined(MBEDTLS_X509_TRUSTED_CERTIFICATE_CALLBACK)
diff --git a/programs/ssl/ssl_test_lib.h b/programs/ssl/ssl_test_lib.h
index 344cd28fd..2e9173055 100644
--- a/programs/ssl/ssl_test_lib.h
+++ b/programs/ssl/ssl_test_lib.h
@@ -43,17 +43,20 @@
 #define MBEDTLS_EXIT_FAILURE    EXIT_FAILURE
 #endif
 
-#if !defined(MBEDTLS_CTR_DRBG_C) ||                         \
-    !defined(MBEDTLS_ENTROPY_C) ||                          \
+#if !defined(MBEDTLS_ENTROPY_C) ||                          \
     !defined(MBEDTLS_NET_C) ||                              \
     !defined(MBEDTLS_SSL_TLS_C) ||                          \
     defined(MBEDTLS_PSA_CRYPTO_KEY_ID_ENCODES_OWNER)
 #define MBEDTLS_SSL_TEST_IMPOSSIBLE                             \
-    "MBEDTLS_CTR_DRBG_C and/or "                                \
     "MBEDTLS_ENTROPY_C and/or "                                 \
     "MBEDTLS_NET_C and/or "                                     \
     "MBEDTLS_SSL_TLS_C not defined, "                           \
     "and/or MBEDTLS_PSA_CRYPTO_KEY_ID_ENCODES_OWNER defined.\n"
+#elif !( defined(MBEDTLS_CTR_DRBG_C) ||                                 \
+         defined(MBEDTLS_HMAC_DRBG_C) && ( defined(MBEDTLS_SHA256_C) || \
+                                           defined(MBEDTLS_SHA512_C) ) )
+#define MBEDTLS_SSL_TEST_IMPOSSIBLE                                     \
+    "Neither MBEDTLS_CTR_DRBG_C, nor MBEDTLS_HMAC_DRBG_C and a supported hash defined.\n"
 #else
 #undef MBEDTLS_SSL_TEST_IMPOSSIBLE
 
@@ -65,6 +68,7 @@
 #include "mbedtls/ssl.h"
 #include "mbedtls/entropy.h"
 #include "mbedtls/ctr_drbg.h"
+#include "mbedtls/hmac_drbg.h"
 #include "mbedtls/certs.h"
 #include "mbedtls/x509.h"
 #include "mbedtls/error.h"
@@ -131,7 +135,13 @@ mbedtls_time_t dummy_constant_time( mbedtls_time_t* time );
 typedef struct
 {
     mbedtls_entropy_context entropy;
+#if defined(MBEDTLS_CTR_DRBG_C)
     mbedtls_ctr_drbg_context drbg;
+#elif defined(MBEDTLS_HMAC_DRBG_C)
+    mbedtls_hmac_drbg_context drbg;
+#else
+#error "No DRBG available"
+#endif
 } rng_context_t;
 
 /** Initialize the RNG.
diff --git a/tests/scripts/all.sh b/tests/scripts/all.sh
index a016732f4..43a6fdd80 100755
--- a/tests/scripts/all.sh
+++ b/tests/scripts/all.sh
@@ -919,10 +919,17 @@ component_test_no_ctr_drbg () {
     CC=gcc cmake -D CMAKE_BUILD_TYPE:String=Asan .
     make
 
-    msg "test: no CTR_DRBG"
+    msg "test: Full minus CTR_DRBG - main suites"
     make test
 
-    # no ssl-opt.sh/compat.sh as they all depend on CTR_DRBG so far
+    # In this configuration, the TLS test programs use HMAC_DRBG.
+    # The SSL tests are slow, so run a small subset, just enough to get
+    # confidence that the SSL code copes with HMAC_DRBG.
+    msg "test: Full minus CTR_DRBG - ssl-opt.sh (subset)"
+    if_build_succeeded tests/ssl-opt.sh -f 'Default\|SSL async private.*delay=\|tickets enabled on server'
+
+    msg "test: Full minus CTR_DRBG - compat.sh (subset)"
+    if_build_succeeded tests/compat.sh -m tls1_2 -t 'ECDSA PSK' -V NO -p OpenSSL
 }
 
 component_test_no_hmac_drbg () {
@@ -954,7 +961,7 @@ component_test_psa_external_rng_no_drbg () {
     msg "test: PSA_CRYPTO_EXTERNAL_RNG minus *_DRBG"
     make test
 
-    # No ssl-opt.sh/compat.sh because they require CTR_DRBG.
+    # no SSL tests as they all depend on having a DRBG
 }
 
 component_test_psa_external_rng_use_psa_crypto () {
@@ -968,7 +975,8 @@ component_test_psa_external_rng_use_psa_crypto () {
     msg "test: full + PSA_CRYPTO_EXTERNAL_RNG + USE_PSA_CRYPTO minus CTR_DRBG"
     make test
 
-    # No ssl-opt.sh/compat.sh because they require CTR_DRBG.
+    msg "test: full + PSA_CRYPTO_EXTERNAL_RNG + USE_PSA_CRYPTO minus CTR_DRBG"
+    if_build_succeeded tests/ssl-opt.sh -f 'Default\|opaque'
 }
 
 component_test_ecp_no_internal_rng () {